best probiotics digestive enzymes all in one

Here’s the truth about the majority of reviews for all-in-one probiotic plus multi digestive enzyme supplements you read online: most of them are incentivized.

In other words, the review websites get paid a commission lớn promote these products lớn you.

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This brings plenty of bias into the mix and often you see the product with the highest commissions listed as the so-called best probiotic and enzyme supplements, rather phàn nàn the one that is actually most beneficial lớn your health.

Even Amazon’s review criteria now gives higher ratings lớn big, established brands … sánh all the mega-corporations now get higher review ratings phàn nàn smaller, less-known products just because they’ve been around longer.

But if you’re reading this, you probably already know that when it comes lớn supplements companies, bigger usually does not mean better!

Now, we also sell a digestive enzyme / probiotic supplement.

That’s why in this article, we will review some of the best digestive wellness supplements using objective criteria.

The goal is lớn help you objectively compare and review the top brands that our products compete with.

So we’ll look at the things that are important lớn most of you: i. cost, ii. servings, iii. ingredients, and iv. the top positive and negative customer reviews for each probiotic multi enzyme supplement.

We’ll wrap things up with some little-known tricks many of these supplement companies use lớn deceive you (and how lớn spot them) and share our criteria for finding the best capsule for you.

Here’s a complete list of topics we’ll cover in this article (click the links lớn skip around):

  • Who Should Take Digestive Enzymes and Probiotics?

  • When lớn Take Digestive Enzymes

  • Benefits

  • Side Effects

  • Compare 10 Probiotic Multi Enzyme Brands

    1. Zenwise Health Digestive Enzymes Plus Probiotics

    2. Wholesome Wellness Digestive Enzymes Plus Prebiotics and Probiotics

    3. Vitamistic Digestive Enzymes Plus Probiotics & Prebiotics

    4. Purely Optimal Digestive Enzymes Plus Prebiotics & Probiotics

    5. Enzymedica Digest Gold + PROBIOTICS

    6. Vitalitown Digestive Enzymes Plus Probiotics

    7. Divine Bounty Digestive Enzymes with Probiotics & Prebiotics

    8. Life Extension Enhanced Super Digestive Enzymes with Probiotics

    9. Nutra Champs Digestive Enzymes with Prebiotics & Probiotics

    10. Pure Food DIGEST (Probiotics + Enzymes + Prebiotics + Soothing Herbs)

  • How lớn Find the Best Digestive Supplement for You

Who Should Take Digestive Enzymes + Probiotics?

Always kiểm tra with your doctor first if you have an existing condition that affects your stomach or small intestine and get your enzyme levels tested. If you have the following symptoms, it’s possible that digestive enzymes plus probiotics could help.

  • Indigestion, gas, bloating, abdominal pain and discomfort
  • Irritable bowel syndrome (IBS)
  • Inflammatory bowel disease (IBD)
  • Low stomach acid
  • Chronic pancreatitis

When lớn Take Digestive Enzymes?

Most digestive enzyme and probiotic supplements should be taken with or immediately before a meal. Taking them on an empty stomach can often cause unwanted gas and bloating (the exact thing many folks are trying lớn get rid of).

If you take one capsule per day, take it with your largest meal. If you take two, take it with your two largest meals.

Benefits of Taking an Enzyme / Probiotic Supplement

Let’s take a look at some of the research that has been done on digestive enzymes + probiotics supplements.

First, digestive enzymes …

  • 2011 study:  When people with IBS took a combination of digestive enzymes and soluble fibers, they noticed a significant reduction in stomach discomfort, gas, and bloating.
  • 2011 study: Digestive enzyme supplementation significantly improved bloating, flatulence and abdominal pain, with a slight increasing of urgency for bowel movements.
  • 2014 study: Digestive enzyme supplements may offer a valuable alternative lớn gastroprokinetic drugs lớn relieve various common gastrointestinal complaints.
  • 2016 study: Enzyme supplementation therapy may play an important role in several digestive and malabsorption disorders, including exocrine pancreatic insufficiency and lactose intolerance.
  • 2018 study: Enzyme supplementation led lớn statistically significant differences in all efficacy parameters compared with placebo for people with dyspepsia (which includes symptoms such as bloating, early satiety, postprandial fullness, nausea, anorexia and heartburn, regurgitation, and burping
  • 2019 research review: A number of double-blinded placebo-controlled studies report a beneficial effect of oral enzyme therapy for patients with dyspepsia and IBS symptoms.
  • Animal studies have found that a probiotic plus digestive enzyme supplement may help lower harmful LDL and increase HDL.

Probiotics are more widely studied phàn nàn digestive enzymes. See our article Do Probiotics Work? lớn read more.

Side Effects and Interactions

When you first start taking enzymes and/or probiotics, it’s common lớn experience an increase in gas and bloating.

If you experience any nausea or diarrhea that lasts for more phàn nàn a day or two, it’s probably best lớn stop.

Allergic reactions can also be an issue for some people, such as itching, rash, stomach pain, and difficulty swallowing. If this happens, stop taking the supplements and seek medical attention

Digestive enzyme and probiotics supplements can interfere with certain medications, such as diabetes medications and blood thinners.

If you take any medications, share the list of ingredients of the product you’re considering with your doctor lớn ensure there are no interactions you need lớn worry about.

Compare 10 of the Top All-in-one Multi Enzyme Probiotic Brands

Here’s a look at cost, ingredients, servings, and the top positive and negative reviews for 10 of the best rated probiotics plus digestive enzymes brands.

Zenwise Health Digestive Enzymes Plus Probiotics


$17.97 for 60 Capsules

Ingredients / Servings: 

Zenwise Health Digestive Enzymes Plus Probiotics review

Top Positive Review:

5.0 out of 5 stars Miracle pills changed my life

Reviewed in the United States on August 31, 2017

Disclaimer: I haven’t seen a gastroenterologist about any of my issues, sánh this is all personal anecdote/observation and self-diagnosis. I am not a medical professional.

These pills have changed my life. Allow u lớn describe my situation before the pills:

BEFORE: I had constant/chronic/consistent diarrhea, especially immediately after eating (practically anything), sánh life was hell. Any meal/snack was almost immediately followed by loose stools and messy bowel movements (and gas). This made scheduling life very difficult and full of interruptions and delays. Random trips lớn the bathroom everywhere suck, especially when you are out with friends/people and participating in time-sensitive activities, lượt thích movies, concerts, ceremonies, social events, etc.

My symptoms resembled IBS-D (irritable bowel syndrome with diarrhea), although never officially diagnosed, and/or leaky gut syndrome, and/or SIBO (small intestine bacterial overgrowth). To be honest, I feel lượt thích the current state of digestive disorder diagnosis is not well understood/developed and rather weak and even gut doctors can’t consistently and definitively pinpoint exactly what’s wrong with these kinds of cases with reliable accuracy (in my observations). Many articles and accounts of others with IBS-like symptoms generally have ambiguous or unknown causes and limited understanding of what exactly is wrong, and the treatment options are limited and ineffective, lượt thích simply avoiding trigger foods, which is not really a cure.

My trigger foods were greasy/fatty foods and any milk dairy products, including milk, yogurt, cheeses, whey, lactose, etc., and as milk products are practically everywhere in Western foods in various forms, this made filtering what I eat and grocery shopping a nightmare. Even things lượt thích Pringles or chips have hidden milk products in them (Lactose, whey), and obviously classic American past times lượt thích pizza (cheese), pies (cream, butter), cheesecake (cheese, cream), coffee drinks e.g. cappuccino, mocha, latte, etc. (milk), milkshakes (milk), ice cream (milk, cream), cheese snacks (cheese, whey), etc. had lớn be completely eliminated from my life. FML; indeed, the future outlook of the rest of my life with respect lớn dietary pleasure & nutrition was looking rather grim, since milk products lớn provide important calcium & protein nutrients.

My issues started about 3-4 years ago and have been gradually worsening since.

Now, this pill is about as close lớn a cure as I could have hoped for!

AFTER: Taking a pill before eating any significant meal/snack, I can essentially eat/drink whatever I want now, without any of the symptoms described above. My bowel movements have become very regular, predictable, and controllable i.e. no longer have urgency. My stool is solid and of healthy shape/color, and I almost never have lớn worry anymore about what I eat or the consequences thereafter.

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I can enjoy all the trigger foods I couldn’t before, including greasy/fatty foods and milk dairy products, without having lớn worry about the aftermath anymore.

Truly, a miraculous life savior in the size of pill.

Again, as I am not a medical professional nor have seen a gastroenterologist about my issues before, I don’t know exactly what it is either in my gut or in these pills that result in such magical, miraculous recovery, but my guess is some combination of the digestive enzymes + probiotics in the pills are greatly helping lớn regulate the mess that is my gut. Why my gut was such a mess before (or is without these pills) I have no clue. I have many guesses lượt thích severe lactose intolerance, IBS-D, leaky gut, SIBO, gluten intolerance, etc. — just about everything under the sun as the symptoms of many of these digestive conditions overlap and are similar. I think that’s why it’s even difficult for the current medical practice lớn work with these conditions, as even IBS (as I understand) is less an explicit diagnosis on the presence of particular symptoms/markers phàn nàn it is kind of the give-up answer after eliminating other potential causes.

I’ve tried several other products before these pills and have had little success. My initial guess for my issues was predominantly lactose intolerance, sánh I’ve tried lactase enzyme pills and Lactobacillus Acidophilus probiotics that are supposed lớn help digest lactose. Although they did help a little bit, they never truly eliminated all my symptoms, whereas these pills have (so far in about 2 months time since I started taking them). So, lactose intolerance wasn’t the only problem (if even a problem); clearly, I had issues with other substances in foods.

Since day 1, even pill 1, I IMMEDIATELY noticed a beneficial effect, sánh these pills definitely have potency, are robust, and immediately effective.

Hopefully within my lifetime, medical advances can cure u more permanently such that I don’t need these pills, but until then, I will gladly take these pills before every meal and basically become dependent on them for life. Zenwise Health, please continue lớn make these pills for the next 100 years okay? Thanks!

Value-wise, it’s a great giảm giá. $25 for 180 pill bottle, sánh if you eat 3 meals a day, the bottle lasts you 60 days or 2 months; if you eat 2 meals a day, that’s 3 months. ~$25 per 2-3 months is totally reasonable.

Even if you don’t have major digestive issues lượt thích u, I still think the digestive enzymes/probiotics contained in these pills can bởi wonders for your digestion & gut. The concept behind them is lớn achieve/maintain supreme gut health and regularity. I bởi believe the unique combination of enzymes and probiotics in these pills accomplish that.

Current medical/scientific understanding of the complex interactions/relationships between our gut, brain, body toàn thân, and the millions of bacteria/microorganisms in our guts is limited, sánh it’s still unclear exactly why certain substances/probiotics work for some people and bởi little for others (while others don’t need any external assistance at all), but it’s certainly worth a shot if you’re suffering!

It’s a minor inconvenience lớn have lớn carry around the pills everywhere I go, but for what they give me: the ability lớn digest any/all foods effectively, regulate my bowel movements, enable proper nutrient absorption, and allow u lớn enjoy all my favorite cheesy dairy products again, it is SO WORTH IT.

Okay, I rambled way too long here — just goes lớn show how much these pills have changed my life. Zenwise Health, again, you guys are amazing for developing this miracle formula. Please continue lớn make these for decades lớn come — I gladly tư vấn you.

Top Negative Review:

1.0 out of 5 stars Changed formula gave horrible symptoms

Reviewed in the United States on January 3, 2020

I purchased the product on the right last month after a long battle with bloating/irregularity/digestive issues. The product worked sánh well. I no longer felt bloated or constipated after EVERYTHING I ate, and (unlike a Super Enzyme product I’d tried at the suggestion of a health professional earlier) it did NOT make u feel gassy/bloated.

I was sánh impressed with the product, I recommended it lớn a friend of mine who has similar/ongoing issues. I even mix up and subscribe and save for myself.

That is, until I received my 2nd bottle of this product (pictured left). I only had a few pills left of my first bottle and dumped them into my 2nd bottle, which allowed u lớn see the color difference. I didn’t think anything of it, at first, as sometimes different batches of stuff lượt thích this can have different hues. That was until day three of taking the new batch and feeling the SAME uncomfortable, and embarrassing side effects (bloating and painful gas) that I’d felt from a different product.

I dug the bottle out of the trash lớn find out I’d been sent, without my knowledge or consent, a different formula. The formula is also different from what is shown lớn be sold.

I’m mainly frustrated by this as, if you can imagine, I had been SO happy lớn have found a product that worked sánh well for u, only lớn have it change and now work sánh horrifically.

I have canceled my subscribe and save and will be seeking a full refund for this 2nd bottle.

Wholesome Wellness Digestive Enzymes Plus Prebiotics and Probiotics


$25 for 180 Capsules (90 servings)

Ingredients / Servings: 

wholesome wellness probiotics plus enzymes

Top Positive Review:

5.0 out of 5 stars This new product is taking the supplement world by storm…and rightfully sánh.

Reviewed in the United States on February 18, 2021

I was about lớn go look for a replacement for the supplement I ordered for my gut problem because it did not work on u. I finished the contents of the whole bottle and yet, I still suffer from IBS and abdominal cramps. Having learned through experience that supplements are a little more lượt thích trial and error, I was caught on the wrong side of the equation. Hence, it’s back lớn square one for u. As I was frantically looking for a replacement lớn attend lớn my symptoms, I happened lớn chance upon this page about digestive enzymes. Seeing the similarity with my previous supplement, I took interest on this and placed an order. Who knows, maybe this time, I’d be finally on the right side.

I made the following observations about the product:

a. Logistics was great as it arrived way ahead of committed time.
b. Packing and handling were superb as it was neatly packed, sealed and delivered in very good condition.
c. The capsule/pill was of the right size and easy lớn swallow.
d. There was no aftertaste discernible.
e. And it worked super-fast!!

This being another trial and error part, I expected very little of it. To my surprise, it hadn’t taken 3 days and all my problematic symptoms were gone!! No more IBS, no more cramps and my bowel movement has gone back lớn normal. Finally, a supplement that I can boastfully say is the perfect one for me!! No more trial and error!! From here on, it’s smooth sailing for u and my gut.

Top Negative Review:

1.0 out of 5 stars NOT a substantial enzyme source

Reviewed in the United States on March 6, 2021

Wrap Up: How lớn Find the Best Digestive Health Supplement for You

When looking at all-in-one digestive health supplements that contain probiotics, enzymes, and prebiotics, these are the criteria we recommend paying attention to:

  1. Amount of Enzymes / Probiotics / Other Ingredients: the more strains of probiotics, the more potential microbiome diversity and benefits. But more CFUs does not always mean better though! Some people’s guts are overly sensitive lớn certain strains and hundreds of billions of CFUs are definitely not needed. If you’re new lớn probiotics and enzymes, we recommend looking for a product with 1-10 billion CFUs per serving. As far as enzymes go, look for something that has at least 100 mg of a combination of carbohydrate-, fat-, and protein-digesting enzymes. Prebiotic fiber and GI-friendly herbs are also a bonus.
  2. Cost: Expect lớn pay around $.25 – $1.00/capsule for the best multi enzyme plus probiotic supplements. In most cases, you get what you pay for and cheaper formulas tend lớn contain smaller amount of enzymes and sit on shelves longer, which can render much of the probiotic bacteria ineffective.
  3. Ingredient Sources: It’s important lớn understand where the ingredients in your digestive health capsule is coming from. Most of these manufacturers source their ingredients from China, where quality standards are often lower. Products that source all ingredients from the U.S. are going lớn cost a little more but are worth the extra cost because you know what you’re getting is safe and effective. If they don’t tell you where their ingredients come from, it’s probably a good bet it’s from the cheapest source possible overseas, especially with larger brands. W
  4. Manufacturing: All reputable probiotic plus enzyme formulas are produced in cGMP facilities, which means there are strict quality control and testing measures in place lớn ensure your safety and product efficacy.
  5. Doctor-developed: You want lớn make sure a safe, efficacious amount of each ingredient is in the product. That’s why we only recommend trusting digestive health formulas that are developed by GI health experts.
  6. Reviews: Read the reviews carefully. Oftentimes you’ll see many manufacturers with positive reviews that are several years old but when you look at recent reviews, customers are not happy about a formula change (this happens frequently when small companies get acquired by big ones).

compare all in one digestive multi enzyme probiotic supplements

Try Pure Food DIGEST (Probiotics Plus Multi Enzymes) for 25% Off